Framework for Optimal Selection Using Meta‐Heuristic Approach and AHP Algorithm

Many real‐life decisions are focused on selecting the most preferable combination of available options, by satisfying different kinds of preferences and internal or external constraints and requirements. Focusing on the well‐known analytical hierarchical process (AHP) method and its extension CS‐AHP for capturing different kinds of preferences over two‐layered structure (including conditionally defined preferences and preferences about dominant importance), we propose a two‐layered framework for identifying stakeholders’ decision criteria requirements and employ meta‐heuristic algorithms (i.e., genetic algorithms) to optimally make a selection over available options. The proposed formal two‐layered framework, called OptSelectionAHP, provides the means for optimal selection based on specified different kinds of preferences. The framework has simultaneously proven optimality applied in software engineering domain, for optimal configuration of business process families where stakeholders’ preferences are defined over quality characteristics of available services (i.e., QoS attributes). Furthermore, this domain of application is characterized with uncertainty and variability in selection space, which is proven and does not significantly violate the optimality of the proposed framework

Configuration of service oriented architectures with semantic technologies based on non-functional requirements

Ова дисертација је фокусирана на примену семантичких технологија за решавање проблема оптималне конфигурације сервисно-оријентисаних архитектура (енгл. Service Oriented Architecture – SOA) на основу нефункционалних захтева корисника. Решење је базирано на проширењу АHP алгоритма за рад са различитим врстама захтева и развоју хеуристичког приступа заснованог на генетичким алгоритмима за решавање проблема оптималне конфигурације. Постојећа решења у овој области су показала изузетно мали ниво персонализације, тј корисницима није дозвољено дефинисање разних софистициранијих врста захтева који осликавају њихове жеље, очекивања и строге захтеве за које захтевају потпуно испуњење. Такође, постојећа решења су била перманентно фокусирана на испуњење захтева функционалности, након чега се врши одабир конфигурације сходно захтевима о смањењу вредности карактеристика које имају тенденцију раста (нпр., цена и време извршавања), односно повећању вредности карактеристика које имају тенденцију опадања (нпр., поузданост и доступност). Међутим, када се посматрају целе фамилије SOA, од посебног значаја постаје проблем конструкције конфигурације при истовременом задовољењу функционалних и нефункционалних захтева. Предложено интегрално решење под називом OptConfSOAFобезбеђује представљање различитих врста захтева (безусловни, условни, захтеви о лексикографском поретку) о нефункционалним карактеристикама и оптималну конфигурацију фамилија SOA на основу дефинисаних захтева. Приступ који се предлаже обезбеђује истовремено задовољење захтева који се тичу функционалности система као и нефункционалних захтева који могу бити различитог нивоа приоритета, односити се на поједине делове или сервисно- оријентисану архитектуру у целости. Предложено решење је опште и није ограничено само на веб сервисе, иако се појам семантичких технологија обично везује за дати домен примене. Решење се може применити у било ком домену у којем се SOA парадигма може применити посматрањем сервиса као било које компоненте (необавезно софтверске) дате функционалности...This dissertation is focused on the application of semantic technologies for solving the problem of optimal configuration of service-oriented architectures (SOA) based on stakeholders’ non-functional requirements. The proposed solution is developed as an extension of the AHP algorithm to allow for processing of different kinds of requirements. To address the problem of optimal configuration of SOA, a heuristic approach based on genetic algorithms has also been proposed and validated. Existing approaches in this field have shown low level of personalization, i.e. stakeholders are neither enabled to define sophisticated requirements that reflect their own expectations and attitudes, nor they are able to indicate hard requirements that have to be fully satisfied. Furthermore, existing approaches were primarily addressing the problem of fulfilling functional requirements, while the selection of an appropriate configuration is driven by the goal of decreasing the values of monotonically decreasing features (e.g., price and execution time) and simultaneous increasing the values of monotonically increasing features (e.g., availability and reliability). By considering the whole SOA families, the problem of configuration based on both functional and nonfunctional requirements gets special importance for research and further applications. The proposed solution, titled OptConfSOAF provides a framework for specification and processing of different kinds of requirements (unconditional, conditional, and requirements about lexicographical order) over non-functional features, and further optimal configuration of SOA families. The proposed approach provides simultaneous fulfillment of functional requirements (i.e., requirements related to the system’s functionalities) and non-functional requirements, where the latter could be defined with different level of importance, for specific parts of a SOA-based system or the system in its entirety. The proposed solution is general and is not bound to web services, even though semantic technologies are often associated with that domain. Since the solution considers a service as a component (no mandatory to be software component) with the specified functionality, it is applicable and easily adaptable to any specific application domain where SOA paradigm may be applied..

Supplementary data for the article: Savić, B. G.; Stanković, D. M.; Živković, S. M.; Ognjanović, M. R.; Tasić, G. S.; Mihajlović, I. J.; Brdarić, T. P. Electrochemical Oxidation of a Complex Mixture of Phenolic Compounds in the Base Media Using PbO2-GNRs Anodes. Applied Surface Science 2020, 529, 147120. https://doi.org/10.1016/j.apsusc.2020.147120

Supplementary material for: [https://doi.org/10.1016/j.apsusc.2020.147120]Related to published version: [https://cherry.chem.bg.ac.rs/handle/123456789/4177

Antioxidant Response in Gills of Eurasian Perch ( Perca fluviatilis ) to Cyanobacterial Bloom Exposure in the Gruža Reservoir

The aim of this study was to assess the impact of an Aphanizomenon flos-aquae bloom in the Gruža Reservoir on the antioxidant parameters measured in the gill cells of Eurasian perch (Perca fluviatilis). Effects of the bloom were evaluated through copper, zinc and manganese containing superoxide dismutase (CuZnSOD and MnSOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST) activities and glutathione (GSH) and sulfydryl (–SH) groups concentrations. The activities of CuZn SOD and Mn SOD decreased during the cyanobacterial bloom compared to the period before the bloom. The opposite trend was observed for CAT and GSH-Px activities that increased. During the bloom GR and GST activities and GSH concentration decreased significantly. CuZn SOD, GR and GST activities are detected as the most important parameters for individual variations. Our results indicated that an A. flos-aquae bloom promotes oxidative stress in the gills of P. fluviatilis. The investigated parameters could be used in environmental risk assessment procedures to monitor the effects of A. flos-aquae blooms on fish. Observed changes in the antioxidant parameters in P. fluviatilis gills make them potential biomarkers in the research of ecological risk situations in freshwater ecosystems with frequent cyanobacterial blooms.Water Research and Management (2016), 6(2): 19-2

Effects of cisplatin on lipid peroxidation and the glutathione redox status in the liver of male rats: The protective role of selenium

The role of oxidative stress in cisplatin (CP) toxicity and its prevention by pretreatment with selenium (Se) was investigated. Male Wistar albino rats were injected with a single dose of cisplatin (7.5 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.) alone or in combination. The results suggest that CP intoxication induces oxidative stress and alters the glutathione redox status: reduced glutathione (GSH), oxidized glutathione (GSSG) and the GSH/GSSG ratio (GSH RI), resulting in increased lipid peroxidation (LPO) in rat liver. The pretreatment with selenium prior to CP treatment showed a protective effect against the toxic influence of CP on peroxidation of the membrane lipids and an altering of the glutathione redox status in the liver of rats. From our results we conclude that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats

Effects of cisplatin on lipid peroxidation and the glutathione redox status in the liver of male rats: The protective role of selenium

The role of oxidative stress in cisplatin (CP) toxicity and its prevention by pretreatment with selenium (Se) was investigated. Male Wistar albino rats were injected with a single dose of cisplatin (7.5 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.) alone or in combination. The results suggest that CP intoxication induces oxidative stress and alters the glutathione redox status: reduced glutathione (GSH), oxidized glutathione (GSSG) and the GSH/GSSG ratio (GSH RI), resulting in increased lipid peroxidation (LPO) in rat liver. The pretreatment with selenium prior to CP treatment showed a protective effect against the toxic influence of CP on peroxidation of the membrane lipids and an altering of the glutathione redox status in the liver of rats. From our results we conclude that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats.U našoj studiji ispitivana je uloga oksidacionog stresa u toksičnosti cisplatina (SR) i njegova prevencija pretretmanom selenom (Se). Mužjaci Wistar albino pacova su inicirani jednom dozom cisplatina (7.5 mg CP/kg t.m., i.p.) i selena (6 mg Se/kg t.m, kao Na2SeO3, i.p.) pojedinačno ili u kombinaciji. Rezultati pokazuju da intoksikacija SR uzrokuje oksidacioni stres i promenu glutation redoks statusa: redukovanog (GSH), oksidovanog (GSSG) i GSH/GSSG indeksa (GSH RI), kao i povećanje lipidne peroksidacije (LPO) u jetri pacova. Tretman Se koji je prethodio tretmanu SR pokazao je zaštitne efekte protiv toksičnog delovanja SR na peroksidaciju lipida membrane i promenu glutation redoks statusa u jetri pacova. Na osnovu naših rezultata zaključujemo da Se, deluje kao snažan antioksidans i da može imati ulogu u kontroli SR indukovane hepatotoksičnosti kod pacova.Projekat ministarstva br. 143035

Chemical synthesis and characterization of lead dioxide nanopowder

Lead dioxide (PbO2) is one of the very interesting materials that have a lot of applications. In this work, nano-sized PbO2 was synthesized by the chemical method. The composition, morphology and crystal structure of the nanopowder were characterized using Fourier Transform Infrared Spectrometry (FT-IR) and field emission scanning electron microscopy with energy dispersive X-ray spectrometer (FESEM-EDX). The obtained data indicate that a nanopowder PbO2 with an average crystalline size of about 20 to 40 nm was formed. The synthesized nanomaterial PbO2 could have a wide range of applications in wastewater treatment, e.g. to remove organic pollutants such as phenols

Antioxidant Response in Gills of Eurasian Perch ( Perca fluviatilis ) to Cyanobacterial Bloom Exposure in the Gruža Reservoir

The aim of this study was to assess the impact of an Aphanizomenon flos-aquae bloom in the Gruža Reservoir on the antioxidant parameters measured in the gill cells of Eurasian perch (Perca fluviatilis). Effects of the bloom were evaluated through copper, zinc and manganese containing superoxide dismutase (CuZnSOD and MnSOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and biotransformation phase II enzyme glutathione-S-transferase (GST) activities and glutathione (GSH) and sulfydryl (–SH) groups concentrations. The activities of CuZn SOD and Mn SOD decreased during the cyanobacterial bloom compared to the period before the bloom. The opposite trend was observed for CAT and GSH-Px activities that increased. During the bloom GR and GST activities and GSH concentration decreased significantly. CuZn SOD, GR and GST activities are detected as the most important parameters for individual variations. Our results indicated that an A. flos-aquae bloom promotes oxidative stress in the gills of P. fluviatilis. The investigated parameters could be used in environmental risk assessment procedures to monitor the effects of A. flos-aquae blooms on fish. Observed changes in the antioxidant parameters in P. fluviatilis gills make them potential biomarkers in the research of ecological risk situations in freshwater ecosystems with frequent cyanobacterial blooms.Water Research and Management (2016), 6(2): 19-2

Effects of cisplatin on lipid peroxidation and the glutathione redox status in the liver of male rats: The protective role of selenium

The role of oxidative stress in cisplatin (CP) toxicity and its prevention by pretreatment with selenium (Se) was investigated. Male Wistar albino rats were injected with a single dose of cisplatin (7.5 mg CP/kg b.m., i.p.) and selenium (6 mg Se/kg b.m, as Na2SeO3, i.p.) alone or in combination. The results suggest that CP intoxication induces oxidative stress and alters the glutathione redox status: reduced glutathione (GSH), oxidized glutathione (GSSG) and the GSH/GSSG ratio (GSH RI), resulting in increased lipid peroxidation (LPO) in rat liver. The pretreatment with selenium prior to CP treatment showed a protective effect against the toxic influence of CP on peroxidation of the membrane lipids and an altering of the glutathione redox status in the liver of rats. From our results we conclude that selenium functions as a potent antioxidant and suggest that it can control CP-induced hepatotoxicity in rats.U našoj studiji ispitivana je uloga oksidacionog stresa u toksičnosti cisplatina (SR) i njegova prevencija pretretmanom selenom (Se). Mužjaci Wistar albino pacova su inicirani jednom dozom cisplatina (7.5 mg CP/kg t.m., i.p.) i selena (6 mg Se/kg t.m, kao Na2SeO3, i.p.) pojedinačno ili u kombinaciji. Rezultati pokazuju da intoksikacija SR uzrokuje oksidacioni stres i promenu glutation redoks statusa: redukovanog (GSH), oksidovanog (GSSG) i GSH/GSSG indeksa (GSH RI), kao i povećanje lipidne peroksidacije (LPO) u jetri pacova. Tretman Se koji je prethodio tretmanu SR pokazao je zaštitne efekte protiv toksičnog delovanja SR na peroksidaciju lipida membrane i promenu glutation redoks statusa u jetri pacova. Na osnovu naših rezultata zaključujemo da Se, deluje kao snažan antioksidans i da može imati ulogu u kontroli SR indukovane hepatotoksičnosti kod pacova.Projekat ministarstva br. 143035

Ispitivanje specifičnosti lipaze iz Candida rugosa u reakciji esterifikacije u organskom rastvaraču

In this study, the feasibility of the synthesis of various flavor esters catalyzed by a commercial lipase from Candida rugosa was investigated and the process parameters were optimized. Lipase from C. rugosa successfully catalyzed the synthesis of 19 esters. The highest yields, of more than 90 % after 20 h, were observed in the synthesis of short-chain esters, pentyl propanoate, isopentyl butanoate, and butyl butanoate. Increasing the number of carbon atoms of both substrates above 8 caused a significant decrease of the initial reaction rates and the final yields. The enzyme showed surprisingly low affinity towards pentanoic acid and hexanoic acid, compared with the higher homologues, octanoic acid and decanoic acid. In addition to the number of carbon atoms, the structure of the substrates had a significant influence on the enzyme activity. Namely, the activity of the enzyme towards isopropanol was significantly lower compared with n-propanol. Additionally, cis-9-octadecenoic acid was a better substrate than octadecanoic acid, its saturated analogue.Cilj ovog rada je bio ispitivanje mogućnosti sinteze različitih estara pomoću lipaze iz Candida rugosa kao i optimizacija procesnih parametara. Pokazano je da se data lipaza može koristiti kao efikasan biokatalizator za dobijanje devetnaest različitih estara. Najveći prinosi, veći od 90%, dobijeni su u slučaju sinteze nižih estara kao što su pentil-propanoat, 2-metilbutil-butanoat i butil-butanoat. Početna brzina sinteze estara i krajnji prinosi bili su znatno niži sa supstratima koji sadrže više od 8 ugljenikovih atoma. Enzim je pokazao iznenađujuće mali afinitet prema pentanskoj i heksanskoj kiselini, u poređenju sa višim homolozima, oktanskom i dekanskom.Pored broja ugljenikovih atoma, na aktivnost enzima značajno je uticalo prisustvo dvostruke veze u molekulu supstrata i razgranatost supstrata. Naime, lipaza iz C. rugosa ispoljila je mnogo manju aktivnost u reakciji sa izopropanolom nego sa propanolom, dok je pokazala mnogo veći afinitet prema 9-cis-oktadecenskoj kiselini u odnosu na njen zasićeni analog, oktadekansku kiselinu